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Nikolai V., Russian physiologist, 1849-1917. See: Eck fistula, reverse Eck fistula.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. Once activated by the ligand ephrin-A1 (EFNA1), it regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signalling pathway. It may participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

During development, EPHA2 may function in distinctive aspects of pattern formation and development of several foetal tissues, such as angiogenesis, early hindbrain development and epithelial proliferation, and branching morphogenesis during mammary gland development. It is thought to regulate lens fibre cells’ shape and interactions and to be important for lens transparency development and maintenance. With ephrin-A2 (EFNA2), it may play a role in bone remodelling by regulating osteoclastogenesis and osteoblastogenesis.

EPHA2 interacts with ACP1, ANKS1A, ARHGEF16, CLDN4, DOCK4, ELMO2, INPPL1, PIK3R1, PIK3R2, PIK3R3, PTK2/FAK1, PTPN11, SLA, VAV2, and VAV3. 

Molecular pathology
Defects in EPHA2 cause cataract cortical age-related type 2 (age-related cataract cortical type 2) and cataract posterior polar type 1 (posterior polar cataracts type 2).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Today, Eck Industries' core competency has evolved into a variety of complex castings with high strength or soundness requirements.
"We tend to work in the low to medium volume range," Tyler Eck said, meaning as few as one or two parts to about 3,000.
"Sometimes you don't get it the first go around because you are a little expensive, but you know you will see it again," Eck said.
The defense and aerospace markets have traditionally been the sweet spot for Eck Industries; it's where the customers that don't mind paying for elevated properties generally can be found.
Because it focuses on higher margin parts, Eck Industries is able to provide a full service shop to its customers, even if that means sacrificing some efficiency.
"The conversation doesn't end if the customer wants to go to permanent mold," Eck said.
Eck admits balancing efficiency with the company's desire to be all things to all people can be tricky.
"Us engineers rely on our supervisors and lean on their experience to get these jobs to go through," Eck said.
What's more, Eck said intangible benefits come from being proficient in multiple processes.
For example, "we are really trying to optimize sand mixer times to service all these different castings," Eck said.