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Nikolai V., Russian physiologist, 1849-1917. See: Eck fistula, reverse Eck fistula.


A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. Once activated by the ligand ephrin-A1 (EFNA1), it regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signalling pathway. It may participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

During development, EPHA2 may function in distinctive aspects of pattern formation and development of several foetal tissues, such as angiogenesis, early hindbrain development and epithelial proliferation, and branching morphogenesis during mammary gland development. It is thought to regulate lens fibre cells’ shape and interactions and to be important for lens transparency development and maintenance. With ephrin-A2 (EFNA2), it may play a role in bone remodelling by regulating osteoclastogenesis and osteoblastogenesis.

EPHA2 interacts with ACP1, ANKS1A, ARHGEF16, CLDN4, DOCK4, ELMO2, INPPL1, PIK3R1, PIK3R2, PIK3R3, PTK2/FAK1, PTPN11, SLA, VAV2, and VAV3. 

Molecular pathology
Defects in EPHA2 cause cataract cortical age-related type 2 (age-related cataract cortical type 2) and cataract posterior polar type 1 (posterior polar cataracts type 2).
References in periodicals archive ?
The way Eck and Weiss tell it, Eck Industries wouldn't be in business without the success of its 200-series alloy programs.
While it has its hand in what seems like a lot of pies, Eck Industries is selective about the R&D projects it takes on.
Eck Industries rarely jumps into a project without another entity providing some funding.
Eck Industries' engineers were aware of the competing theories on how to castin nanoparticles, and they knew improved properties could be achieved in small batches.
How does Eck Industries know the market for these improved materials exists?
Most of Eck Industries' marketing comes via word of mouth.
I have heard numerous customers say they have tried other places, and they said take that to Eck," Weiss said.
It's a reputation that goes back to the tradition of 200-series success established by Robert Eck, Tyler's grandfather.
Today, Eck Industries' core competency has evolved into a variety of complex castings with high strength or soundness requirements.