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Nikolai V., Russian physiologist, 1849-1917. See: Eck fistula, reverse Eck fistula.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. Once activated by the ligand ephrin-A1 (EFNA1), it regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signalling pathway. It may participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

During development, EPHA2 may function in distinctive aspects of pattern formation and development of several foetal tissues, such as angiogenesis, early hindbrain development and epithelial proliferation, and branching morphogenesis during mammary gland development. It is thought to regulate lens fibre cells’ shape and interactions and to be important for lens transparency development and maintenance. With ephrin-A2 (EFNA2), it may play a role in bone remodelling by regulating osteoclastogenesis and osteoblastogenesis.

EPHA2 interacts with ACP1, ANKS1A, ARHGEF16, CLDN4, DOCK4, ELMO2, INPPL1, PIK3R1, PIK3R2, PIK3R3, PTK2/FAK1, PTPN11, SLA, VAV2, and VAV3. 

Molecular pathology
Defects in EPHA2 cause cataract cortical age-related type 2 (age-related cataract cortical type 2) and cataract posterior polar type 1 (posterior polar cataracts type 2).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
* I can't imagine how she'll feel when she finds out Eck is gone The blaze broke out early yesterday and four fire engines raced to the house just before 6am.
18, 19, and 23, and to some extent also 20 and 21), should have been separated into a section of their own, or perhaps even better, should have joined Eck's many other studies regarding this unique, highly significant, and poorly understood clash between Jews and the Roman Empire, and been bundled into a stand-alone book.
"There has been tremendous interest from industry due to the unique material properties and low cost of this alloy," said David Weiss, vice president of engineering/R&D, Eck. "This project is a template for rapid development and commercialization.
Van Eck Global has announced that the Van Eck Long/Short Equity Fund has been renamed the Van Eck Long/Short Equity Index Fund.
College students are getting an object lesson in progressvism, Eck suggests.
The Trackers business for Van Eck Global will be led by Marc Freed, Mark Hurrell and Ben McMillan.
But the story behind the recently released Eck App offers lessons in patience, taking creativity to new heights and showing how a company can stretch its mission boundaries while having plenty of fun in the process.
Defeat against Spurs could send the Blues down - just months after Eck landed the club's first trophy since 1963 by defeating mighty Arsenal in the Carling Cup Final.
The fund's sponsor, Van Eck Global, created new shares in exchange for cash for a day after the Egyptian market first closed.