echothiophate


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echothiophate

 [ek″o-thi″o-fāt]
an anticholinesterase, used as the iodide salt for topical application to produce miosis, decrease intraocular pressure, and potentiate accommodation in treatment of open-angle glaucoma, closed-angle glaucoma after iridectomy, and certain secondary types of glaucoma, and in the management of accommodative esotropia.

echothiophate

(ek″ō-thī′ŏ-fāt″)
A cholinergic drug used topically in the eye for treatment of glaucoma.
References in periodicals archive ?
Compound Docking scores (kcal x [mol.sup.-1]) Trichlorfon -5.7 Echothiophate -5.9 Isoflurophate -5.9 Pyridostigmine -6.3 Neostigmine -7.5 Parathion -7.6 Rivastigmine -7.9 Tacrine -8.8 Ladostigil -9.1 Physostigmine -9.1 Huperzine A -9.7 Ungeremine -10 Galantamine -10.2 Donepezil -12.1 2 -9.1 3 -9.4 6 -7.8 7 -5.7 8 -7.6 9 -7.9 14 -10
Echothiophate iodide treatment of glaucoma in pregnancy.
Topical application of 0.03% echothiophate iodide or 0.025% Isoflurophate (both organophosphates) has been successful for T.
Examples of organophosphates include insecticides (Malathion, parathion, diazinon, fenthion, dichlorvos, chlorpyrifos, ethion), nerve gases (Soman, sarin, tabun, VX), ophthalmic agents (Echothiophate, isoflurophate), and anthelmintics (Trichlorfon).
For echothiophate iodide (Phospholine Iodide), there is one case report of a normal full-term infant whose mother was treated with the agent up to 32 weeks' gestation and then with pilocarpine for 8 weeks (Arch Ophthalmol.
In the present study, we evaluated this possibility by measuring light emission upon stimulation with KCI or veratridine of synaptosomes pretreated with 47 [micro]mol [1.sup.-1] of echothiophate iodide, an acetylcholinesterase inhibitor.
* Subjects who are on myotics like carbachol, demecarium, echothiophate, isoflurophate, neostigmine and physiostigmine.