congenital syphilis

(redirected from Early congenital syphilis)

con·gen·i·tal syph·i·lis

syphilis acquired by the fetus in utero, thus present at birth.
Farlex Partner Medical Dictionary © Farlex 2012

congenital syphilis

Congenital lues, fetal syphilis Neonatology Transplacental infection with Treponema pallidum Clinical Early–hepatomegaly, irritability, FTT, fever, perioral and genital rash–condyloma lata, nasal discharge or snuffles and saddle nose; late–Hutchinson's teeth, saber shins, neurologic impairment, deafness, blindness Lab ↑ liver enzymes, anemia, monocytosis Diagnosis Serologic tests performed at birth may be negative. See Syphilis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

con·gen·i·tal syph·i·lis

(kŏn-jen'i-tăl sif'i-lis)
Syphilis acquired by the fetus in utero, thus present at birth.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

congenital syphilis

SYPHILIS acquired by the fetus from the mother during pregnancy and present at birth. Congenital syphilis may feature severe early skin rashes, often occurring in the first 10 weeks of life, bone and cartilage defects, liver and kidney disturbances, damage to the corneas (interstitial keratitis), deafness, peg teeth, saddle-shaped nose and scars at the angles of the mouth. Treatment is with penicillin.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

con·gen·i·tal syph·i·lis

(kŏn-jen'i-tăl sif'i-lis)
Syphilis acquired by the fetus in utero, thus present at birth.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
There have been case reports of hypopituitarism as a result of early congenital syphilis, which may cause prolonged hypoglycaemia in these neonates; however, this was unlikely in our study population owing to resolution of hypoglycaemia with no systemic features suggestive of hypopituitarism.'311 These findings indicate that despite hypoglycaemia not being a statistically significant risk factor for death, it should be anticipated in neonates with congenital syphilis.
Although the majority of infants with congenital syphilis are asymptomatic at birth, among symptomatic ones, clinical manifestations of early congenital syphilis include skin rash, snuffles, jaundice, hepatomegaly with or without splenomegaly, fever, generalized lymphadenopathy, and failure to thrive [5, 7, 8].
The most common cutaneous finding of early congenital syphilis is a symmetrical, copper-red maculopapular rash [1, 7,10] Less commonly, the eruption maybe in the form of acral skin desquamation, acral vesiculobullae (pemphigus syphiliticus), mucous patches, petechiae, erythema multiformelike targetoid lesions, perioral/perinasal/perianal fissures, and condylomata lata [1,4, 6, 7,10,13].
Our patient had clinical manifestations of early congenital syphilis such as acral skin desquamation, perioral fissures, snuffles, hepatomegaly, failure to thrive, Coombs-negative hemolytic anemia, and thrombocytopenia.
Here we report a newborn with early congenital syphilis presenting with maculopapular rash and positive treponemal test born to an inadequately treated syphilitic mother.
In early congenital syphilis, the most common finding in infected infants is hepatomegaly and is observed in almost all infected infants (7).
Syphilis can also be transmitted in utero from mother to foetus and there are two types of congenital syphilis: early congenital syphilis (with emergence of lesions during the first two years of life and late congenital syphilis, the analogue of secondary syphilis) (7).
Early congenital syphilis emerges in the first two years of life, and skin lesions are much like the secondary syphilides from the acquired syphilis: papular, papuloscuamous syphilides, deeply fissured papules of the mouth angles or the nostrils, condylomata lata (usually in the first year, hardly in the newborn period), pemphigus syphiliticus: bullae on the red infiltrated base, localized on the palms and soles, with rupture and leaving exuding areas.
Early congenital syphilis may feature a flulike syndrome associated with hemorrhagic nasal discharge (snuffles), a hoarse cry, multinodal lymphadenopathy, purpura, hepatosplenomegaly, ascites, mucocutaneous lesions (including mucous patches), and perioral fissuring (rhagades).