EYA2

EYA2

A gene on chromosome 20q13.1 that encodes an eyes absent (EYA) family protein, which is thought to play a role in eye—and possibly muscle—development.
References in periodicals archive ?
Other miR-30 mediated targets directly related to cell proliferation are Eya2, HP1y (CBX3), EZH2, IGF1R, RPA1, Notch, and IRS2.
Finally, miR30a also mediates G1 cell cycle arrest by targeting Eya2, concomitant with decreased c-Myc, cyclin A, cyclin D1, and cyclin E expression in breast cancer [11] (Figure 3).
Furthermore, miR-30a also inhibits breast cancer cell migration through inhibiting Eya2 [11], EYA2 [52], DTL [53], insulin receptor substrate 2 (IRS2) [42], SEPT7 [6], and Skp2 [54] expression.
Kang et al., "MiR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2," Biochemical and Biophysical Research Communications, vol.
Li et al., "Overexpression of MIR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2," Acta Biochimica et Biophysica Sinica, vol.
Similarly, miR-30a also regulates directly the target genes, such as Eya2, HP1y (CBX3), EZH2, IGF1R, RPA1, Notch, IRS2, SOX4, Runx2, DTL, ATF3, MYC, HIF2a, and SEPT7, which are all involved in regulating cell proliferation procedure.
Following the transplantation of PDL-MSCs into the in vivo tendon defect animal models, the cells could differentiate into tenocytes that expressed tendon markers including Tnmd, Eya1, Eya2, and SCX and induced tendon regeneration [20].
(ii) Increased Collagen Ia1, Ia2, and tendon related transcription factor Eya2 in SCX cells compared to control.
We did not detect mRNA of the atypical MKPs DUSP13, DUSP15, DUSP26, and DUSP27, the classical MKP DUSP9, the tensin homolog TPTE, the eyes absent EYA1, EYA2, and EYA4, and the myotubularin MTMR7.
Similar observations were seen in overexpression of MyoD in P19 embryonal carcinoma stem cells, which can induce paraxial mesodermal genes including Meox1, Pax3, Pax7, Six1, and Eya2 followed by muscle-specific genes.