RUNX1

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RUNX1

A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is thought to be involved in the development of normal haematopoiesis. 

Molecular pathology
Chromosomal translocations involving RUNX1 are well documented and associated with several types of leukaemia.
References in periodicals archive ?
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
In [O.sub.2.sup.-] generation, significant inhibitions compared to control were observed at concentrations more than 10 [micro]g/ml for EVI-1, for EVI-2 and for EVI-4 (Dunnett's multiple comparison test).
Effect of EVI-1,2 and 4 on [O.sub.2.sup.-] and O[H.sup.[dot]] generated in PMA-stimulated human neutrophils
Treatment of the cells with EVI-1, EVI-2 and EVI-4 (all 300 [micro]g/ml) suppressed the PMA-induced [O.sub.2.sup.-] and O[H.sup.[dot]] production (Fig.
However, each component of eviprostat at the equivalent dose to EVIs at 1350 mg/kg (that is, EVI-1 at 37.5 mg/kg, EVI-2 at 37.5 mg/kg, EVI-3 at 37.5 mg/kg, EVI-4 at 112.5 mg/kg, and EVI-5 at 1125.0 mg/kg) had no effect on the paw edema (Fig.
In the present study, we found that EVI-1, EVI-2 and EVI-4 quenched [O.sub.2.sup.-] and O[H.sup.[dot]] and that EVI-3 quenched O[H.sup.[dot]].
EVI-1, EVI-2 and EVI-4 had no effect on the rate of uric acid production in the xanthine/xanthine system, suggesting that these components act as [O.sub.2.sup.-] scavengers.