RUNX1

(redirected from EVI-1)
Also found in: Acronyms.

RUNX1

A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is thought to be involved in the development of normal haematopoiesis. 

Molecular pathology
Chromosomal translocations involving RUNX1 are well documented and associated with several types of leukaemia.
References in periodicals archive ?
In the present study, we found that EVI-1, EVI-2 and EVI-4 quenched [O.
EVI-1, EVI-2 and EVI-4 had no effect on the rate of uric acid production in the xanthine/xanthine system, suggesting that these components act as [O.
Since several ROS are involved in inflammatory processes (Lee and Peehl, 2004), the anti-ROS activities of EVI-1, EVI-2 and EVI-4 may contribute to the anti-inflammatory action of eviprostat.
According to Physicians Desk Reference for Herbal Medicine (Fleming, 2000), Chimaphila umbellata, the source of EVI-1, contains hydroquinone glycosides such as isohomoarbutin and homoarbutin, and naphthoquinone derivatives such as chimaphilin, which are known to have urinary antiseptic effects.