ETV1

ETV1

A gene on 7p21.3 that encodes a transcription activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Jonkers et al., "MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours," British Journal of Cancer, vol.
Currently, the EPS family is defined by the presence of specific translocations frequently involving the EWSR1 gene, which is fused to an E26 transformation-specific (ETS) family gene (FLI-1, ERG, or ETS variant 1 (ETV1)) [10].
Furthermore, imatinib, as a tyrosine kinase inhibitor for c-KIT or PDGFRA, is extensively used in treating GST.[sup][5] We also found in this study that the expression of ETV1 gene, a member of the ETS family, is obviously upregulated.
YWHAE is among the 14-3-3 proteins that regulate the ETV1 transcription factor in PCa [26].
Recently, ETV1, as the main downstream effector of SCF/Kit signaling, was also found to be necessary for the normal development of ICC.
Jonkers et al., "MiR-1792 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours," British Journal of Cancer, vol.
(47) Several other ERG rearrangements have been reported in prostate cancer, including rearrangements involving the ETS family members ETV1 (7p21.2) and ETV4 (17q21) as well as the RAF kinase gene.
[4] Human genes: TMPRSS2, transmembrane protease, serine 2; ERG, v-ets erythroblastosis virus E26 oncogene homolog (avian); SLC45A3, solute carrier family 45, member 3; ETV1, ets variant 1; NDRG1, N-myc downstream regulated 1.
Abbott will develop a molecular assay based on its proprietary FISH (fluorescence in situ hybridisation) technology to detect rearrangements of the ERG and ETV1 genes and measure loss of the PTEN gene.
Researchers examined three specific genetic alterations in prostate cancer samples from 308 patients: Loss of the PTEN tumor suppressor gene, and rearrangement of two others--the ERG or ETV1 genes.
Jonkers et al., "MiR17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours," British Journal of Cancer, vol.
Toyomasu et al., "Platelet-derived growth factor receptor-a regulates proliferation of gastrointestinal stromal tumor cells with mutations in KIT by stabilizing ETV1," Gastroenterology, vol.