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As shown in Figure 2, statistical analysis of network nodes in the transcription factor regulatory network diagram found more than 10 nodes that had 44 genes, of which there were 20 nodes that had more than 4 genes, including IL-6, ETS2
, TNF, and OPN1MW (Table 4).
The first of these studies reported a combination of the E26 transformationspecific (ETS) TF family member ETS2
and MESPl proteins to induce reprogramming of human dermal fibroblasts to cardiac progenitors .
Lien et al., "EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2
transcriptional repressor ERF," Cancer Research, vol.
Core Idea: ETS2
.B: Influence of engineering, technology, and science on society and the natural world
Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2
, and ERG genes.
RuvBl2 cooperates with Ets2
to transcriptionally regulate hTERT in colon cancer.
In experimental diabetic animals, miR-320 is transferred from cardiomyocytes to endothelial cells by exosomal activity and this transfer regulates endothelial cells migration and tube formation by downregulating IGF-1, Hsp20, and Ets2
Zhang, "Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by downregulating the MDM2 oncogene through the PI3K/mTOR/ ETS2
pathway," Cancer Research, vol.
The human ETS2
gene was cloned into PCDNA3.1, with an HA tag and the human TFEB promoter, and the fragments were inserted into PGL3-basic vectors.
Moreover, RUNX1 registered mid values of over expression in CN, Pu and GP; BRWD1, CLIC6, ETS2
, and SH3BGR had low levels of expression.