ETS1

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ETS1

A gene on chromosome 11q23.3 that encodes ETS1, a DNA-binding  transcription factor that regulates numerous genes and is involved in stem cell development, cell senescence and death, and tumourigenesis.
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References in periodicals archive ?
This study was designed to identify and characterize novel inhibitor of Ets-1 by using virtual screening approach combined with biological evaluation of anti-angiogenic ability of compound.
This study revealed a potential inhibitor of Ets-1 and anti-cancer mechanism of saffron.
Ets-1 is a prototypic member of the E-26 (Ets) family of transcription factors that share a unique DNA- binding domain the Ets domain (Yordy et al.
It is well established that Ras-responsive phosphorylation of a conserved residue threonine-38 in the N-terminal region of Ets-1 strongly increases its transcriptional activity (Wasylyk et al.
However despite all of the recent advances in computational chemistry and/or drug discovery nothing has been reported till date in the context of Ets-1 small molecule inhibitors.
Ets-1 (RCSB Protein Data Bank code: 2JV3) was examined.
The 3-D crystal structure of Ets-1 PNT (Pointed) domain 29-138 (Pdb ID: 2jv3) was retrieved from protein data bank (http://www.rcsb.org/pdb).
Amino acid sequence of Ets-1 was retrieved from PDB and is shown below.