EDNRB

(redirected from ET-B)

EDNRB

A gene on chromosome 13q22 that encodes endothelin-B receptor, a member of the endothelin receptor group of G-protein-coupled
receptors, located primarily in the vascular endothelial cells where they play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation.

Molecular pathology
EDNRB mutations cause Hirschsprung disease type 2.
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References in periodicals archive ?
Two endothelin receptor subtypes, designated ET-A and ET-B, reside on pulmonary endothelial and smooth-muscle cells.
Animal and human studies have suggested that, whereas ETA is strongly implicated in the etiology of PAH, ET-B's role may be beneficial, and therefore that a selective ET-A blocker might be desirable.
Animal and human studies have suggested that, whereas ET-A is strongly implicated in the etiology of PAH, ET-B's role may be beneficial, and therefore that a selective ET-A blocker might be desirable.