beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.
References in periodicals archive ?
Ten isolates of Gram negative with resistance to ceftazidime, cefotaxime and ceftriaxone were selected to detect ESBL enzyme by using DDST.
Various drug resistance mechanisms of Enterobacteriaceae include extended spectrum [beta]-lactamases (ESBL) production, AmpC [beta]-lactamases production, efflux mechanism, plasmids, and porin deficiency.
In the 137 strains studied, 14 different molecular profiles were found for ESBL-producing bacteria although only six different types of ESBL were observed (CTX-M-1 group, CTX-M-2 group, CTX-M-9 group, TEM-like, SHV-like, PER-1-like, and GES-10-like).
Prevalence and risk factors for intestinal carriage of CTX-M-type ESBLs in Enterobacteriaceae from a Thai community.
By placing a disc of ceftazideme/ clavulanic acid as extra disc for ESBL detection in E.
Other ESBL isolates were recovered from swabs (49, 14%), followed in decreasing order by blood (36, 10.2%), sputum (32, 9.1%) and other (16, 4.6%).
Table 1: Characteristics of ESBL, Amp C and MBLs (As adopted from Pitout, 2012) S.
ESBLs are plasmid-mediated [beta]-lactamases that are capable of hydrolyzing [beta]-lactams, except for carbapenems and cephamycins.
coli isolates identified as ESBL producers, 29 (88%) were resistant to amoxicillin-clavulanic acid, 28 (85%) to ceftazidime, 27 (82%) to trimethoprim-sulfamethoxazole, and 25 (76%) to ciprofloxacin.
Of the 208 Enterobacteriaceae identified during the study period, 45 (21.6%) were ESBL positive.