embryonic stem cell

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embryonic stem cell

totipotent cells composing the inner cell mass of the blastocyst.

embryonic stem cell

Abbreviation: ES cell
A cell from the inner cell mass of the blastocyst (the 3-5 day old mammalian embryo) that can give rise to all the somatic cells of the body. Embryonic stem cells can be maintained as pure stem cell cultures.
See: adult stem cell
See also: cell

embryonic stem cell (ESC)

1. A cell taken from an early embryo and intended for therapeutic application of its totipotential property.
2. A cell derived from an embryo resulting from a donated egg whose nucleus has been removed and replaces by a cell from a prospective patient. During pregnancy some ESCs pass across the placental barrier and enter the mothers bloodstream. There are suggestions that these stem cells may repair damaged maternal organs, including the brain. Cells can be derived from umbilical cord blood that appear to have most of the properties of ESCs.
References in periodicals archive ?
ES cells were transiently transfected by the vectors constitutively expressing mHIF-1[alpha] or mHIF-2[alpha].
Other breakthroughs, such as the ability to induce pluripotency in adult cells (iPS cells) may bring the debate over ES cells to an end.
The present study demonstrated that angioblast-like cells could be obtained from mouse ES cells and the transplantation of the angioblast-like cells, ES-AB, improved several physiological impairments in DPN: hypoalgesia, delayed NCVs, and reduced blood flow in sciatic nerves and plantar skin.
Cryopreserved ES cells or iPS cells should be stored at -150[degrees]C or in the vapor phase of liquid nitrogen.
Their genetic manipulation allows targeted mutagenesis that can be transferred to the whole organism, by means of chimeras containing ES cells in the germ line [16].
We observed no expression of Ahr mRNA in ES cells, but it was detectable in 2-day-old EBs; Ahr expression gradually increased to a maximum by 6 days of differentiation and maintained a constant level for the next 8-9 days (Figure 1C).
A second method measured IGF-1 receptor levels in ALDH-sorted ES cell lysates using the Luminex xMAP antibody-based protein quantification assay.
Only 3 of these registered trials are using ES cells and all are, as yet, without data to substantiate therapeutic success.
Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation.
Evidence for an in vitro differentiation of ES cells into the neuronal lineage has been reported (10,11).
This process is described in footnote 3, supra; it raises special considerations because of the inherent capacity for reproductive cloning if ES cells are derived from the cells that divide first (the blastomere stage).