ERN1

ERN1

A gene on chromosome 17q24.2 that encodes the ubiquitously expressed endoplasmic reticulum (ER)-to-nucleus signalling 1 protein, which has intrinsic kinase and endoribonuclease activities and plays a key role in altering gene expression in response to endoplasmic reticulum-based stress signals. ERN1 senses unfolded proteins in the ER lumen, leading to enzyme auto-activation; the active endoribonuclease domain splices XBP1 mRNA, generating a new C-terminus and converting it into a potent unfolded-protein response transcriptional activator, triggering growth arrest and apoptosis.
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Venn diagram analysis revealed that 6 upregulated genes (CISH, ERLIN1, FCRL1, IL1A, RPS6KA2, and SOCS3) and 9 downregulated genes (ADORA3, ARRDC3, BCOR, ERN1, FRAT1, HBB, KLHDC8B, TIGD3, and ZNF217) were present in the responses of neutrophils to either iRBC or LPS stimulation (Figures 1(d) and 1(e)).
Minchenko, "ERN1 knockdown modifies the hypoxic re gulation of TP53, MDM2, USP7 and PERP gene expre ssions in U87 glioma cells," Ukrainian Biochemical Journal, vol.
On the other hand, in the second case the following marker genes are described: (i) proliferation regulation including 11 genes, CD24, NRP1, TNS3, MYC, CD38, CCNA2, FGF7, MST1R, MYCN, ETS1, and EDNRA, and (ii) cell death related regulation including 12 genes: DDIT3, ERN1, JUN, SQSTM1, SMPD1, TGFB1, PRNP, CEBPB, NQO1, NR4A1, CTSB, and ZMAT3.