MAPK3

(redirected from ERK-1)

MAPK3

A gene on chromosome 16p11.2 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK3 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
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The mRNA expression of prometastatic genes such as MMP-2, MMP-9, ERK-1, ERK-2 and VEGF was found to be upregulated in the lung tissues of metastatic-tumour control animals (Fig.
In this study, the expression of ERK-1, ERK-2, and VEGF have been downregulated and as supporting evidence the serum VEGF level was also reduced by the treatment.
The binding of ras to raf causes raf to phosphorylate and thereby activate MAPK (also known as MAPK/ERK kinases 1 and 2), which in turn activates the next set of downstream kinases, ERK-1 (extracellular receptor-stimulated kinase 1) and ERK-2 (extracellular receptor-stimulated kinase 2).
An immunoperoxidase reaction for ERK-1 and ERK-2 (ERK-1 [K23] and ERK-2 [C14], Santa Cruz Biotechnology, Santa Cruz, Calif) was performed on each case using an avidin-biotin complex method.
In 16 of 17 verrucous carcinomas, the most basally situated layers of epithelial cells minimally stained with ERK-1 and ERK-2 (Figure 3).
In particular, the mitogen-activated protein kinases ERK-1 and ERK-2 (extracellular signal-regulated protein kinases 1 and 2) are acutely activated by many extracellular stimuli and by oncogene products (10).
Activation of MAP kinase ERK-1, -2, and SRE-dependent transcription by TPA or EGF.
These results establish that there are thresholds of activation of ERK-1, ERK-2, AP-1, or NF[kappa]B above which there is risk of transformation by TPA, EGF, or TNF[alpha].
We exposed XTC-2 cell monolayers to hydrogen peroxide or bacterial lipopolysaccharide and measured ERK activation by Western blotting using antibodies raised against phosphorylated ERK-1 and ERK-2.
The antibody is reactive with ERK-2 and to a lesser extent ERK-1 and possesses broad interspecies reactivity (murine, human, chicken, and frog).
We detected only ERK-2 (p42 MAP kinase) in XTC-2 cells, whereas both ERK-1 and ERK-2 were readily detectable in human lung fibroblasts (Figure 1).