TRPM2

(redirected from EREG1)

TRPM2

A gene on chromosome 21q22.3 that encodes a nonselective,  voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.
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References in periodicals archive ?
Among genes that control cell proliferation, we observed overexpression of the gene EREG1, which plays an autocrine role in the proliferation of corneal epithelial cells [54], and APLP2 gene, involved in corneal epithelial wound healing [55].