EDEM1(redirected from ER degradation-enhancing alpha-mannosidase-like 1)
EDEM1A gene on chromosome 3p26.1 that encodes an enzyme directly involved in endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It interacts with DERL2 and DERL3.
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