EPS8

EPS8

A gene on chromosome 12p12.3 that encodes epidermal growth factor receptor kinase substrate 8, which is thought to be involved in transducing signals from Ras to Rac and in growth factor-mediated actin remodelling.
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Johnson et al., "The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells," PLoS One, vol.
RO G BULK A0 A1 1.63e-9 76.9 5.79e4 0.0 0.0 EPS2 EPS3 EPS4 EPS5 EPS6 0.113 0.176 0.246 0.296 0.352 P2 P3 P4 P5 P6 14.98 29.15 59.18 98.10 179.44 RO A2 PC VCR REF EPS1 1.63e-9 0.467 -0.0069 0.0 0.0 0.0 EPS2 EPS7 EPS8 EPS9 EPS10 P1 0.113 0.395 0.433 0.467 0.47 0.0 P2 P7 P8 P9 P10 14.98 289.44 450.20 650.65 800.0 TABLE 5: Design values of beam specimen [18].
Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages.
Bhat et al., "P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers," Cell Communication and Signaling, vol.
"Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3," Biochemical Journal 435(3): 553-562.
"Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3," Spermatogenesis 1(4): 291.
2006), presumably by targeting epidermal growth factor receptor pathway substrate (Eps8), a member of the protein family regulating actin polymerization.
Chang et al., "Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages," Journal of Biological Chemistry, vol.
"Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium," FASEB Journal 23(8): 2555-2567.