EPHX2

EPHX2

A gene on chromosome 8p21 that encodes epoxide hydrolase-2. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX2 mutations are associated with familial hypercholesterolaemia.
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References in periodicals archive ?
However, EETs are degraded to corresponding diols by a soluble epoxide hydrolase (sEH) that is encoded by the EPHX2 gene on chromosome 8p21-p12 [9].
Accordingly, we tested the hypothesis that an association exists between EPHX2 rs751141 and risk of DN in the Chinese with T2D and whether Hcy level affects this association.
Kabcenell et al., "Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice," The Journal of Biological Chemistry, vol.
Other five genes, DUSP1, EPHX2, NUDT1, RNF7, and SEPP1, demonstrated a statistically significant modulation in poor prognosis patients in three out of six tumor types (Figure 3 and Suppl.
One of the strongest signs came from the gene EPHX2, which codes for epoxide hydrolase 2-an enzyme known to regulate cholesterol metabolism.
The scientists continued to find evidence that certain variants of EPHX2 occur more frequently in people with anorexia.
EPHX2, a gene that we studied, encodes soluble epoxide hydrolase (sEH), which degrades epoxyeicosatrienoic acids (EETs) to corresponding diols [15].
Based on these observations, we performed genetic association analyses in a cohort of Chinese T2DM population from Beijing, China, aiming to evaluate the association of the combined effect of MTHFR C677T and EPHX2 G860A on ischemic stroke.
In addition, SNPs present in metabolism and DNA repair genes were selected a priori by the consortium as candidate genes based on the available knowledge on functionalities with respect to bioactivation (CYP1A1, CYP2E1, CYP2D6, EPHX1, and EPHX2) and detoxification (GSTM1) of DNA adduct-forming metabolites, base excision repair of oxidative adducts (OGG1), nucleotide excision repair of bulky adducts (XRCC1, ERCC2/XPD, XPA, and XRCC3), repair of alkylated adducts (MGMT, ALKB, and MPG) and of thymine adducts (TDG), and with respect to folate metabolism, which is known to interfere with micronucleus formation (MTHFR, MTR, and MTRR).
SNPs in EPHX1, EPHX2, and CYP2E1 were significantly associated (unadjusted overall p-value < 0.05) with the frequency of MNBN lymphocytes (Table 4).
Decreased: 6 mice from ATP5 [alpha] 3,15-18 months and [beta] of age Liver Livers from EPHX2, Acaal, Pipox, [89] male C57BL6/J Amy2a, Decr2, Phb2, mice of 10- COX6c, UQCRC2 week-old and 18-month-old.
The CGA approach may be limited because of probe selection in the Affymetrix Styl array.Among 498 SNPs associated with candidate genes, only 9 were located within exons {CYPJA2, ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2), EPHX1 [epoxide hydrolase 1, microsomal (xenobiotic)], EPHX2, CYP26B1, GSTM3 (glutathione S-transferase mu 3 (brain)], and CYP4B11 and 87 were located within introns.