EPHX1

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EPHX1

A gene on chromosome 1q42.1 that encodes epoxide hydrolase-1. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX1 mutations variously cause pre-eclampsia, epoxide hydrolase deficiency or increase epoxide hydrolase activity.
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References in periodicals archive ?
The genetic study revealed an increase in EPHX activity (wild-type allele in homozygosity for SNP rs1051740 and heterozygosity for SNP rs2234922).
Our research group has been working on this topic with phenytoin; in this case, EPHX is involved in arene oxide detoxification, so we started to investigate EPHX polymorphisms in patients with AED therapy [29, 30].
Even though there is no current evidence of microsomal EPHX involvement in arene oxide detoxification in the case of LTG and no formation of dihydrodiol was reported in the literature, EPHX participation is chemically possible and cannot be disregarded.
Uria et al., "Role of CYP2C9, CYP2C19 and EPHX polymorphism in the pharmacokinetic of phenytoin: a study on Uruguayan Caucasian subject," Pharmaceuticals, vol.