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EPHB6A gene on chromosome 7q33-q35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases. EPHB6 binds to ephrin-B ligands, but lacks kinase activity; it inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression when stimulated by ephrin-B2. EPHB6 interacts with CBL, EPHB1 and FYN, and is expressed in the brain, pancreas, and in in situ breast carcinoma cell lines.
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