EPHB6


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EPHB6

A gene on chromosome 7q33-q35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases. EPHB6 binds to ephrin-B ligands, but lacks kinase activity; it inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression when stimulated by ephrin-B2. EPHB6 interacts with CBL, EPHB1 and FYN, and is expressed in the brain, pancreas, and in in situ breast carcinoma cell lines.
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Another restriction phenomenon is the preferred expression of the EphB6 gene in brain and thymus.
Some members even show rather restrictive expression: e.g., EphB6 expression was highest in the thymus (111-fold compared with the calibrator tissue).
Furthermore, we have recently found a loss of EphB6 expression in malignant melanomas (37), whereas other receptors, such as EphA2, and ligands, such as ephrin-B2, are up-regulated (6, 7).
Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.