EPHB4

EPHB4

A gene on chromosome 7q22 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. With its cognate ligand/functional ligand EFNB2, EPHB4 plays a central role in heart morphogenesis and angiogenesis by regulating cell adhesion and cell migration. EPHB4-mediated signalling controls cellular repulsion and segregation form EFNB2-expressing cells. EPHB4 also plays a role in postnatal blood vessel remodelling, morphogenesis and permeability, as occurs in tumour angiogenesis.
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In addition, both ephrin-B2 and its receptor EphB4 are expressed in mature monocytes and lymphocytes and regulate their motility, adhesion, transmigration, and the secretion of inflammatory mediators [17].
Zhang et al., "Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta," The Journal of Clinical Endocrinology & Metabolism, vol.
Briefly in maintaining homeostasis of bone remodeling, osteoclasts express ephrinB2, a transmembrane ligand, while osteoblasts express the EphB4 receptor.
Several organ- or tumor-specific markers, such as CEA (carcinoembryonic antigen), EGFR (epidermal growth factor receptor), PSA (prostate-specific antigen), HER-2 (human epidermal growth factor receptor 2), MUC-1 (mucin 1), EphB4 (ephrin type-B receptor 4), IGF-1R(insulin-like growth factor 1 receptor), cadherin 11, and CSV (cell-surface vimentin) have also been reported for antibody-based isolation of CTCs (see online Supplemental Table 1).
Nesland, "Expression of Ephb2 and Ephb4 in breast carcinoma," Pathology and Oncology Research, vol.
En este sentido, se ha observado que genes como efirina B2 y EphB4 se expresan en endotelio arterial y venoso respectivamente, antes que la circulacion este totalmente madura (Wang et al., 1998).
Huang et al., "Peptide-conjugated polymeric micellar nanoparticles for Dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts," Biomaterials, vol.
Fu et al., "Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients," Clinical and Translational Oncology, vol.
The cellular analysis of the two-color immunofluorescence in ventral horn of the rat spinal cord showed a colocalization of the EphA1, EphA2, EphA7, EphA8, EphB1, EphB4, and EphB6 receptors, as well as the ephrin A5 with the NF-200 positive motor neurons of this region.
EphB4 is a receptor tyrosine kinase that is expressed on epithelial cells during fetal life.