EPHB3

EPHB3

A gene on chromosome 3q21-qter that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB3 has a largely overlapping and redundant function with EPHB2: both play roles in axon guidance during development; in regulating the neurons; and in forming the corpus callosum and anterior commissure, two major interhemispheric connections between the temporal lobs of the cerebral cortex. The redundancy extends to the development and maturation of dendritic spines and formation of excitatory synapses. It is also involved in regulating cell migration and positioning, angiogenesis, and development of the palate and thymic epithelium.
References in periodicals archive ?
Ma et al., "Upregulation of the long noncoding RNA FOXD2-AS1 promotes carcinogenesis by epigenetically silencing EphB3 through EZH2 and LSD1, and predicts poor prognosis in gastric cancer," Oncogene, vol.
Another lab study [71] indicates that tyrosine kinase EphB3 produces deleterious effects on maintaining synaptic stability and plasticity after TBI.
Liebl, "EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain," Neurobiology of Disease, vol.
In vivo studies and gene expression profiling experiments have shown that EhpB2 and EphB3 are both Wnt target genes and are expressed in the proliferative cells at the crypt bottom [113].
In mouse model, it has been confirmed that the activation of EPH receptor associated genes, like EPHB3, contributes to the onset of epilepsy [74].
Yuan et al., "Up-regulated ephrinB3/ EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model," Brain Research, vol.
In contrast to the abovementioned restrictions, the EphB3 and EphB4, EphA1, EphA2, and EphA7 genes are widely expressed.
The Wnt target genes, EphB2, EphB3, and their ligands ephrins, are key coordinators of migration and proliferation in the stem cell niche.
Whittemore, "Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression," Cell Transplantation, vol.
Moreover, ephrinB3 is able to bind to both EphB3 and EphA4 receptors [120].