EPHB2


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EPHB2

A gene on chromosome 1p36.1-p35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB2 functions in axon guidance during development, guiding commissural axons and forming a major interhemispheric connection between the two temporal lobes of the cerebral cortex. EPHB2 is also involved in the guidance of contralateral inner ear efferent growth cones at the midline, and of retinal ganglion cell axons to the optic disk. It also regulates dendritic spines development and maturation, and it stimulates the formation of excitatory synapses.

Activation of EPHB2 by EFNB1 abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. EPHB2 also controls other aspects of development, including angiogenesis, palate development, as well as inner ear development by regulating endolymph production. It may act as a tumour suppressor.

Molecular pathology
Defects in EPHB2 have been linked to prostate cancer.
References in periodicals archive ?
Siegbahn, "The Eph tyrosine kinase receptors EphB2 and EphA2 are novel proteolytic substrates of tissue factor/coagulation factor Vila," Journal of Biological Chemistry, vol.
Siljamaki et al., "EphB2 promotes progression of cutaneous squamous cell carcinoma," Journal of Investigative Dermatology, vol.
Ephb2 SNPs and sporadic prostate cancer risk in African American men.
EPHB2 showed an age-dependent decrease in expression level (P < 0.001) from 2 to 6 WOA and then increased at 8 WOA, but diet did not affect EPHB2 expression, nor did the interaction between age and diet (Figure 4(b)).
Closer examination revealed that all of the birds with crests carried a single change in the EphB2 gene.
Citation: "EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool"; E.
Using software developed by paper co-author Mark Yandell, a geneticist at the University of Utah, the scientists revealed that a single mutation in a gene named EphB2 causes head and neck feathers to grow upward instead of downward, creating head crests.
In addition to EphB2, secreted factors (i.e., S1P and MCP-1) keep the osteoclast and osteoblast activity closely coupled (see Figure 2).
et al (2007) Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation and inhibition of cancer growth.
We expanded the initial ToxCast assay portfolio to include additional biochemical assay targets known to be critical in vascular development: VEGFreceptors VEGFR1, VEGFR2, and VEGFR3;the arterial vessel marker EphB2 (ephrin-B2);and PI3Ka (phosphatidylinositol 3-kinase) andPTEN (phosphatase and tensin homolog), bothof which have been shown to govern normalvascular development (Chappell et al.
Expression and function of ephrin-B1 and its cognate receptor EphB2 in human atherosclerosis: from an aspect of chemotaxis.
The protein is an enzyme called EphB2 and plays a crucial role in neurotransmission - the passing of nerve messages between neurons by means of chemical signals.