EPHA7

EPHA7

A gene on chromosome 6q16.1 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EFNA5 is a cognate/functional ligand for EPHA7, and together they regulate brain development by modulating cell–cell adhesion and repulsion. EPHA7 has repellent activity on axons and is involved in guiding corticothalamic axons (and, in the proper topographic mapping, retinal axons) to the colliculus. It may also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signalling may result in activation of components of the ERK signalling pathway, including MAP2K1, MAP2K2, MAPK1 and MAPK3, which are phosphorylated in response to EPHA7 activation.
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The same effect of decreased inhibition on LTP was shown in a recent in vivo study where the knockdown of the receptor tyrosine kinase EphA7, which is implicated in gephyrin clustering, led to a specific reduction in perisomatic basket cell-granule cell synapses and decreased LTP at perforant path-granule cell synapses [76].
Horovitz et al., "Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells," Scientific Reports, vol.
In a recent study, a direct requirement was shown for the binding of a specific ligand (ephrinA5) to a specific type of receptor (EphA7) in order to enable adhesion to occur in the neural tube [243].
EphA1, EphA4, and EphA7 are expressed at the crypt bottom, while EphA2, EphA5, and the ephrin-A1 ligand are enriched at the upper colonic crypts [20].
In our prediction list, five genes can be classified in such subfamily: EPHA3, EPHA4, EPHA5, EPHA7, and EPHB2.
This research involved testing the involvement of EphA7 with a2 integrin using three cell types, NMuMG1, NMuMG3 and X2C2.
For EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrin-B3, immunohistochemistry was established to visualize some conclusive patterns of tissue-specific expression.
Immunohistochemistry was performed for EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrinB3.
In contrast to the abovementioned restrictions, the EphB3 and EphB4, EphA1, EphA2, and EphA7 genes are widely expressed.
EphA7 was up-regulated 25-fold in hepatocellular carcinomas compared with healthy liver tissue, and EphB2 was up-regulated 9-fold in this carcinoma.
The cellular analysis of the two-color immunofluorescence in ventral horn of the rat spinal cord showed a colocalization of the EphA1, EphA2, EphA7, EphA8, EphB1, EphB4, and EphB6 receptors, as well as the ephrin A5 with the NF-200 positive motor neurons of this region.