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The same effect of decreased inhibition on LTP was shown in a recent in vivo study where the knockdown of the receptor tyrosine kinase EphA7, which is implicated in gephyrin clustering, led to a specific reduction in perisomatic basket cell-granule cell synapses and decreased LTP at perforant path-granule cell synapses .
Horovitz et al., "Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells," Scientific Reports, vol.
In a recent study, a direct requirement was shown for the binding of a specific ligand (ephrinA5) to a specific type of receptor (EphA7) in order to enable adhesion to occur in the neural tube .
EphA1, EphA4, and EphA7 are expressed at the crypt bottom, while EphA2, EphA5, and the ephrin-A1 ligand are enriched at the upper colonic crypts .
In our prediction list, five genes can be classified in such subfamily: EPHA3, EPHA4, EPHA5, EPHA7, and EPHB2.
This research involved testing the involvement of EphA7 with a2 integrin using three cell types, NMuMG1, NMuMG3 and X2C2.
For EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrin-B3, immunohistochemistry was established to visualize some conclusive patterns of tissue-specific expression.
Immunohistochemistry was performed for EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrinB3.
In contrast to the abovementioned restrictions, the EphB3 and EphB4, EphA1, EphA2, and EphA7 genes are widely expressed.
EphA7 was up-regulated 25-fold in hepatocellular carcinomas compared with healthy liver tissue, and EphB2 was up-regulated 9-fold in this carcinoma.
The cellular analysis of the two-color immunofluorescence in ventral horn of the rat spinal cord showed a colocalization of the EphA1, EphA2, EphA7, EphA8, EphB1, EphB4, and EphB6 receptors, as well as the ephrin A5 with the NF-200 positive motor neurons of this region.
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- ependymal cell
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- EPH-like tyrosine kinase 2
- EPH-like tyrosine kinase-2
- EPH-related receptor transmembrane ligand ELK-L3
- EPH-related receptor tyrosine kinase ligand 1
- EPH-related receptor tyrosine kinase ligand 2
- EPH-related receptor tyrosine kinase ligand 3
- EPH-related receptor tyrosine kinase ligand 4
- EPH-related receptor tyrosine kinase ligand 5
- EPH-related receptor tyrosine kinase ligand 6
- EPH-related receptor tyrosine kinase ligand 7
- EPH-related receptor tyrosine kinase ligand 8
- EPHA Environment Network
- EphA10s protein
- ephaptic transmission
- EphB31 Embryonic kinase 2