EPHA7A gene on chromosome 6q16.1 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EFNA5 is a cognate/functional ligand for EPHA7, and together they regulate brain development by modulating cell–cell adhesion and repulsion. EPHA7 has repellent activity on axons and is involved in guiding corticothalamic axons (and, in the proper topographic mapping, retinal axons) to the colliculus. It may also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signalling may result in activation of components of the ERK signalling pathway, including MAP2K1, MAP2K2, MAPK1 and MAPK3, which are phosphorylated in response to EPHA7 activation.
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