(36) Here, we describe Ephrin receptor A10 (EphA10), which was identified as a novel breast cancer-related protein expressed in many breast cancer tissues but not normal breast tissues.
(2005) Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.
Signal transduction studies have suggested that cell membrane bound SOD3 increases the phosphorylation of the cell membrane tyrosine kinase (RTK) receptors, epidermal growth factor receptor (EGFR), erb-b2 receptor tyrosine kinase 2 (ERBB2), receptor-like tyrosine kinase (RYK), anaplastic lymphoma kinase (ALK), Fms-like tyrosine kinase 3 (FLT3), Ephrin A10 (EPHA10
), and VEGF-R [45, 67, 75]; cell membrane-associated signaling molecules, such as the SRC proto-oncogene family members HCK, FYN, SRC, YES, and LYN; and cytoplasmic signaling molecules, including AKT, glycogen synthase kinase 3 (GSK3), and [beta]-catenin .
A TaqMan [R] probe/primer set was designed for real-time reverse transcription-PCR (RT-PCR) for the detection and quantification of gene expression of all currently known human members of the Eph receptor and ephrin family except for EphA5 and EphA10
. For EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrin-B3, immunohistochemistry was established to visualize some conclusive patterns of tissue-specific expression.