The over-expression of EpCAM
protein was proved in the majority of neoplasms, among the others, in eosophageal cancer, pancreatic cancer and gastric cancer [10-12].
Generic marker fluorescence-triggered scatter plots of EpCAM
vs generic marker fluorescence (A-E) or side scatter (F).
: structure and function in health and disease," Biochimica et Biophysica Acta, vol.
This study identified 12 (29.3%) EPCAM
positive tumors and 29 (70.7%) negative tumors.
Giepmans, "Absence of cell-surface EpCAM
in congenital tufting enteropathy," Human Molecular Genetics, vol.
Andrisani, "Hepatitis B virus X protein induces EpCAM
expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2," Oncogene, vol.
Several aptamers, including those targeting EpCAM
, TfR (CD71 or the transferrin receptor), CD30, PSMA, and a T-cell marker, have been conjugated to NPs (Figure 4(b)) [81-86].
Epithelial cells in general, and epithelial derived tumor cells in particular, express the epithelial cell adhesion protein (EpCAM
) and different cytokeratins (CKs), which are absent in normal white blood cells .
(2011) Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM
is not associated with worse prognosis in pancreatic ductal adenocarcinoma.
As shown in Figure 3, laminin-derived signaling induced no significant transcriptional down-regulation of octamer-binding transcription factor 4 (OCT4), homeobox transcription factor nanog (NANOG), epithelial cellular adhesion molecule (EPCAM
), THY-1 T-cell antigen (THY1), or ubiquitin carboxyl-terminal esterase L1 (UCHL1) throughout the entire culture period.
Epithelial cell markers EpCAM
, cytokeratins 8, 18, and 19 were also assessed.
Other investigated markers included, for instance, CY-FRA 21-1 (cytokeratin 19-fragments), cancer antigen 15.3 (CA), CA 125 (MUC 16), calretinin, carcinoembryonic antigen, intelectin-1, human mammoglobin, tissue polypeptide antigen, VEGF (vascular endothelial growth factor), EMA (endomysial antibody), Ber-Ep4 (mouse monoclonal EpCAM
antibody), TTF-1 (thyroid transcription factor-1) or hyaluronic acid [30,31,39-42].