EPCAM


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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
The over-expression of EpCAM protein was proved in the majority of neoplasms, among the others, in eosophageal cancer, pancreatic cancer and gastric cancer [10-12].
Generic marker fluorescence-triggered scatter plots of EpCAM vs generic marker fluorescence (A-E) or side scatter (F).
Giepmans, "EpCAM: structure and function in health and disease," Biochimica et Biophysica Acta, vol.
This study identified 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors.
Giepmans, "Absence of cell-surface EpCAM in congenital tufting enteropathy," Human Molecular Genetics, vol.
Andrisani, "Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2," Oncogene, vol.
Several aptamers, including those targeting EpCAM, TfR (CD71 or the transferrin receptor), CD30, PSMA, and a T-cell marker, have been conjugated to NPs (Figure 4(b)) [81-86].
Epithelial cells in general, and epithelial derived tumor cells in particular, express the epithelial cell adhesion protein (EpCAM) and different cytokeratins (CKs), which are absent in normal white blood cells [14].
(2011) Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreatic ductal adenocarcinoma.
As shown in Figure 3, laminin-derived signaling induced no significant transcriptional down-regulation of octamer-binding transcription factor 4 (OCT4), homeobox transcription factor nanog (NANOG), epithelial cellular adhesion molecule (EPCAM), THY-1 T-cell antigen (THY1), or ubiquitin carboxyl-terminal esterase L1 (UCHL1) throughout the entire culture period.
Epithelial cell markers EpCAM, cytokeratins 8, 18, and 19 were also assessed.
Other investigated markers included, for instance, CY-FRA 21-1 (cytokeratin 19-fragments), cancer antigen 15.3 (CA), CA 125 (MUC 16), calretinin, carcinoembryonic antigen, intelectin-1, human mammoglobin, tissue polypeptide antigen, VEGF (vascular endothelial growth factor), EMA (endomysial antibody), Ber-Ep4 (mouse monoclonal EpCAM antibody), TTF-1 (thyroid transcription factor-1) or hyaluronic acid [30,31,39-42].