HIV-1 gene

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HIV-1 gene

Any of the genes present in the human immunodeficiency virus. See AIDS.
HIV genes
art/trs gene rev gene, see there.
env gene Encodes viral coat proteins gp 120 and gp 41, which mediate CD4 binding and membrane fusion, controlled by tat and rev
gag gene Encodes nucleocapsid core proteins including p24
nef gene 3´ orf, B gene, ORF-2 gene Encodes a protein of unknown function found in infected Pts that may down-regulate viral expression–nef deletion results in a five-fold increase in viral DNA synthesis and replication
pol gene Encodes reverse transcriptase, protease, integrase and ribonuclease
R gene Encodes TAR–transcription activating response element, which has a nonspecific immunodeficiency effect
rev gene art/trs gene Encodes a 19 kD post-transcriptional protein regulator required for HIV replication, up-regulating HIV synthesis by transactivating anti-repression, ↑ levels of envelope RNA by regulating the env gene; inactivation of rev prevents viral replication–as measured by the successful production of the p24 glycoprotein by infected monocytes can be massively ↑ by adding cytokines to culture medium
tat gene Encodes a potent 14 kD transcription activator that amplifies HIV replication, the inactivation prevents viral replication
vif gene Facilitates infectivity of free HIV
vpr gene Encodes a weak transcription activator
vpu gene Unique to HIV-1, encodes a 16 kD product which, when mutated, has a 5-10-fold Ø in replicative capacity and is critical for efficient budding of virions NEJM 1991; 324:308rv
†Gene encoding regulatory protein
‡Gene encoding structural protein
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References in periodicals archive ?
Copies of Env study the surface of HIV; their chief function is to grab hold of host cells and break into them to initiate infection.
ENV patron and former Olympian David Moorcroft MBE said: "One of the many successes of the London Olympics was the impact of the local volunteers who helped to make it happen.
ENV is notably uncommon; its exact incidence is unknown.
The emphasis of recent studies on the role of ITD ENV in spatial hearing and speech-in-noise perception has been more than was expected.
Deeper integrations between ENV 2 and Finance Logix's software are expected to be rolled out before the end of this year.
In Env. 3 only, participants wore eye-tracker glasses (Applied Science Laboratories Mobile Eye-XG Eye Tracking Glasses).
LG enV TOUCH also allows users to read documents from any microSD card in several file formats including .doc, .xls, .ppt and .pdf and features 3" external touch screen / 3" internal screen and a 3.2 megapixel camera/camcorder with autofocus, flash and image editor.
"The ENV (Emissions Neutral Vehicle) bike was engineered and purpose-built from the ground up, based around Intelligent Energy's world-beating CORE fuel cell, to demonstrate the real, everyday applicability of fuel cell technology," said the World Economic Forum.
Seymourpowell director, Nick Talbot, said: "ENV is light, fast and fun.
Allan Zelaya a la distancia tu papito Rub?n te felicita por tus 7 a?os y te env?a todo su amor porque siempre te lleva en el coraz?n.
In this work, we demonstrate the ability of this genetic vaccine to provoke robust HLA-A*0201-restricted T cell responses in MHC class I humanized mice against gag, pol, env, and nef after a single round of immunization.
If completed, Laidlaw's 66% stake in its Laidlaw Env. unit would drop to about 38% which would allow Laidlaw to remove the related debt from its balance sheet and make it easier for Laidlaw to finance growth in its core transportation business.