MRC2

(redirected from ENDO180)

MRC2

A gene on chromosome 17q23.2 that encodes a C-type lectin domain protein which may play a role as a lectin receptor by internalising glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. Mannose receptor C-type 2 may play roles in plasminogen activation by controlling the extracellular level of PLAUR/PLAU; in cellular uptake and remodelling, and in degradation of extracellular collagen matrices; in cancer and chronic tissue-destructive diseases acting on collagen turnover; and may participate in extracellular matrix remodelling in concert with matrix metalloproteinases.
References in periodicals archive ?
C-type mannose receptor 2 (MRC2, also known as ENDO180, CD280, or uPARAP) plays a supporting role in bone development being involved in collagen trafficking and deposition [53].
The human ASM-MR cDNA (5658 bp) is 99% identical to the EST clone KIAA0709 (5641 bp; adult human brain), and the coding region is identical to that of MRC2 cDNA (Endo180, 4639 bp).
4:50 pm: The importance of cleaning the damaged dermal collagen fibers on anti-photoaging: Roles of Endo180 on collagen fiber remodeling--Hiroyasu Iwahashi, Maruzen Pharmaceuticals Co., Ltd.
Popov et al., "A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion," PLoS ONE, vol.
Collagens participate in cell-matrix interactions acting as functional ligands of several receptor families including glycoprotein VI (GPVI), inhibitory leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), Endo180 (urokinase-type plasminogen activator-associated protein), integrins, and dimeric discoidin receptors (DDR1 and DDR2) [83-85].