S100A12

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S100A12

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A12-encoded protein may be involved in calcium-dependent signal transduction pathways; its regulatory effect on cytoskeletal components may modulate neutrophil activities and trigger the release of cytokines.
References in periodicals archive ?
Lee et al., "Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis," Atherosclerosis, vol.
Kim et al., "Circulating levels of soluble receptor for advanced glycation end product are inversely associated with vascular calcification in patients on haemodialysis independent of S100A12 (EN-RAGE) levels," Nephrology (Carlton), vol.
Qureshi et al., "Effect of circulating soluble receptor for advanced glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in hemodialysis patients," Clinical Journal of the American Society of Nephrology, vol.
Bresnihan et al., "Expression of the proinflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis," Rheumatology, vol.
Kraft et al., "Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease," Gut, vol.
Vogl et al., "S100A12 (EN-RAGE) in monitoring Kawasaki disease," Lancet, vol.