EMX2

EMX2

A gene on chromosome 10q26.1 that encodes a transcription factor which, in co-operation with EMX1, generates the boundary between the roof and archipallium in the developing brain. EMX2 is expressed in embryonic and adult olfactory neuroepithelia, where it forms a complex with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelia and is downregulated by HOXA1.
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Several studies evidenced data suggesting that EMX2 gene may be involved in the modulation of cell proliferation of cortical neuroblasts and/or cell migration of postmitotic neurons, as it is known that these cells reach their final destination in the mature cortex according to their generation date.
The fifteenth round of sixteen was played out in bright sunshine and high temperatures and was also the site of the final meeting in the EMX2 competition.
63) Kim et al (59) reported the differential expression of PLSCR4 (phospholipid scramblase) and EMX2 using real-time polymerase chain reaction.
EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors.
Etyolojisinde IU donemde organik cozuculere maruz kalma, hipoksik-iskemik olaylar, CMV ve kabakulak enfeksiyonu suclanmis, ayrica EMX2 "homebox" geninin mutasyonu ile meydana geldigi de ileri surulmustur (12, 13).
Que la alteracion genetica no este presente en todos los casos, y que el mismo compromiso genetico se manifieste con expresion variable, sugiere que la perdida de la funcion en el gen EMX2 puede ser el primer paso de un mecanismo patogenico de mayor complejidad en el que otros factores podrian influir en la gravedad y la extension de las lesiones.
13 En algunos de estos pacientes no se ha encontrado la mutacion en el gen EMX2, pero por otra parte si se ha observado que esta infeccion viral esta asociada con alteraciones vasculares.
Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly.
El desarrollo de las crestas obedece a la accion de un grupo de genes como WT1, SF1, DAX1, Lim1, EMX2, LHX9, situados en cromosomas autosomicos (1).
Some familial cases have been reported were heterozygous germline mutations of homeobox gene EMX2 are often encountered.
Loss-of-function mutations in EMX2 have been described in individuals with the radiological diagnosis of schizencephaly (9).