EMX1

EMX1

A gene on chromosome 2p13.2 that encodes a transcription factor which, in co-operation with EMX2, generates the boundary between the roof and archipallium in the developing brain. EMX1 may function in combination with OTX1/2 to specify cell fates in the developing CNS.
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The WDR11 gene product partners EMX1, a homeodomain transcription factor involved in the development of olfactory neurons.
Importantly, NeuroD6, by forming a coexpression network module with TBR1, FEZF2, FOXG1, SATB2, and EMX1, plays a key role in development of the human neocortex and hippocampus projection neurons that are severely degenerated in AD brains [33].
Kurth et al., "WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome," American Journal of Human Genetics, vol.
Anth-hbxB of Metridium is most similar to empty-spiracles homologs from the mouse (EMX1 and EMX2).