Although the incidence of vulvar EMPD is rare, several reports described heterochronous development of EMPD in the vulva and MPD , even synchronous development of EMPD of the vulva and MPD lesions [6-9].
Previously, AR-positive rates of 88% in MPD and 78% in EMPD were described by Liegl et al.
remains an "extraordinarily hard tumor to treat.
Several studies have attempted to use IHC to differentiate primary from secondary EMPD
, but the immunoprofiles tend to overlap, including occasional CK20 and prostatespecific antigen expression in primary EMPD
In cases of longstanding and persistent forms of the condition, an attempt should be made to rule out EMPD
. Finally, oral supplements should be given for cases occurring as a result of nutritional deficiency.
We collected archival formalin-fixed paraffin-embedded skin specimens from 5 patients with noninvasive EMPD
and 5 patients with invasive EMPD
treated at the Department of Dermatology at Tohoku University Graduate School of Medicine.
Extramammary Paget's disease (EMPD
) is a rare neoplasm of apocrine gland-bearing skin such as vulva, perianal region, scrotum and penis.1 However, it has also been described in other apocrine gland-bearing areas including axillae, thigh, face, eyelids, face, abdomen, external auditory canal.1,2 It is defined as marginated plaque resembling Paget's disease clinically and histologically.
Between 14% and 54% of patients with vulvar EMPD
have an underlying carcinoma at presentation, as do between 69% and 73% of patients with perianal EMPD
Primary extramammary Paget disease (EMPD
) was the most common (49 of 56 cases; 88%), and 29% (14 of 49) of EMPD
cases were associated with an invasive component.
The effective mean penetration depth (EMPD
) model in EnergyPlus was used to account for moisture storage in building constructions.
Gruning, "Power Supply quality improvement with a dynamic voltage restorer (DVR) in Proceedings of EMPD
'98, Singapore, Mar.
In some practical applications, when only an estimate of the indoor climate is of interest, this can be done using simplified models for moisture buffering, such as Effective Moisture Penetration Depth (EMPD