EML4

EML4

A gene on chromosome 2p21 that encodes echinoderm microtubule-associated protein-like 4, which is thought to modify the assembly dynamics of microtubules.
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Various ALK gene arrangements, or translocations, have been observed in NSCLC; the majority of variants involve gene fusions between the ALK and EML4 genes.
Chou y colaboradores [1] sugieren que en estudios recientes han demostrado que algunos CPT llevan un gen de fusion oncogenica causada por translocacion del gen cinasa del linfoma anaplasico (ALK) con varios socios, incluyendo EML4 limitado, GFT y GTF2IRD1, y hasta la fecha solo se han identificado en los CPT y carcinomas pobremente diferenciados y anaplasico (presumiblemente derivados de diferenciacion del CPT) que sugieren que las translocaciones ALK pueden ser mas comun en los subtipos agresivos de CPT.
ALK fusions are observed in ~4% of NSCLC patients (8), resulting from an inversion of EML4 and ALK gene on the short arm of chromosome 2 which constitutively activates the kinase and protein oligomerization (9).
The ALK mutations seen in NSCLC occur as a result of a fusion between echinoderm microtubule-associated proteinlike 4 (EML4) and ALK (Figure 3).
(7) EML4 encodes a microtubule-associated protein with a coiled-coil domain, and ALK encodes a receptor-type protein tyrosine kinase.
Target Full Name Context Pct Score ASH1L ashl (absent, small, or -0.59 > homeotic)-like (Drosophila) 0.99 RICTOR rapamycin-insensitive companion of -0.57 > mTOR 0.99 ITGB8 integrin, beta 8 -0.62 0.98 C20orf194 chromosome 20 open reading frame -0.72 0.97 194 SNF1LK SNF1-like kinase -0.39 0.97 FAM44B family with sequence similarity 44, -0.65 0.95 member B C10orf18 chromosome 10 open reading frame 18 -0.87 0.95 ZCCHC14 zinc finger, CCHC domain containing -0.5 0.94 14 AFF1 AF4/FMR2 family, member 1 -0.25 0.94 EML4 echinoderm microtubule associated -0.42 0.93 protein like 4 LCOR ligand dependent nuclear receptor -0.33 0.93 corepressor CCDC6 coiled-coil domain containing 6 -0.33 0.92 BNC2 basonuclin 2 -0.32 0.9 Apoptosis signaling is associated with miR-125b predicted targets.
In some patients with non-small cell lung cancer (NSCLC), fusion of anaplastic lymphoma kinase (ALK) gene and EML4 gene promotes lung cancer cell growth, especially if they have adenocarcinoma subtype of lung cancer.
[6] Human genes: EML4, Echinoderm microtubule associated protein like 4; ALK,ALK receptor tyrosine kinase; EGFR, epidermal growth factor receptor; KRAS, KRAS proto- oncogene, GTPase.