ELK4

ELK4

A gene on chromosome 1q32 that encodes a member of the ETS family of transcription factors and ternary complex factor (TCF) subfamily, which form a complex by binding to the serum response factor and serum reponse element in the c-fos proto-oncogene promoter. ELK4 is activated by MAPK1 and MAPK8 signal-induced phosphorylation.
References in periodicals archive ?
For gga-miR-302b-5p, RASGRF2, MAP3K4, NLK, and ELK4 are the best target genes (Figure 14).
In this network, genes with the highest out-degree are SP1, MAZ, ELF4, ELF1, ELF2, SPI1, ELK1, ELK4, GABPA, and GABPB2.
ELK4 ELK4 plays important roles in cell growth regulation of prostate cancer cells.
A human protein ELK4, which is predicted to bind, may be influenced by the degree of methylation in the promoter of some genes as demonstrated in the caldesmon gene (CALD1) by Cooper et al.
The ETS gene family includes ERG, ETTV1, ETTV4, ETV5, and ELK4. The most common fusion is TMPRSS2:ERG, which has a prevalence of approximately 40% to 70%.