ELK1

ELK1

A gene on chromosome Xp11.2 that encodes a member of the ETS family of transcription factors and ternary complex factor (TCF) subfamily, which form a complex by binding to the serum response factor and serum reponse element in the c-fos proto-oncogene promoter. ELK1 is a nuclear target for the ras-raf-MAPK-signalling cascade.
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MiR-143 has been proved to have an anti-cancer effect by targeting multiple genes related to cell proliferation, apoptosis and migration, such as Bcl-2 (13), MYO6 (14), ELK1 (15), and ERK5 (16).
The ERK signaling pathway involves an additional protein, ELK1 which interacts with ERK2 to activate the genetic information.
However, at 20h after infection, AKT2, ELK1, c-Jun, c-Fos, NF-[kappa]B p65, PI3K and STAT1 in EV71-infected RD cells were up-regulated and exhibited 2.