MiR-143 has been proved to have an anti-cancer effect by targeting multiple genes related to cell proliferation, apoptosis and migration, such as Bcl-2 (13), MYO6 (14), ELK1
(15), and ERK5 (16).
In this network, genes with the highest out-degree are SP1, MAZ, ELF4, ELF1, ELF2, SPI1, ELK1
, ELK4, GABPA, and GABPB2.
Top IIb exhibits preferential binding and cleavage at the promoters of target nIEGs, cooccupying the site with the transcriptional activator ELK1
and histone deacetylase HDAC2, the latter repressing nIEG expression .
Li et al., "Thyroid transcription factor 1) interacts with ETS factor ELK1
to co-regulate TERT," Oncotarget, vol.
(vii) The nucleus (location tag NUc) contains several proteins (Atf1, Creb1, Elk1
Alternatively, upregulation of miR-34a in senescent HDFs may be independent of p53 and modulated by other transcription factor, such as ELK1
Following MAPK signaling, the activation of transcriptional factors such as E-26 like protein 1 (ELK1
), activating transcription factor 2 (ATF-2), STAT, c-fos, c-Jun, and AP-1 in the COX-2 promoter region can increase COX-2 expression .
The ERK signaling pathway involves an additional protein, ELK1
which interacts with ERK2 to activate the genetic information.
However, at 20h after infection, AKT2, ELK1
, c-Jun, c-Fos, NF-[kappa]B p65, PI3K and STAT1 in EV71-infected RD cells were up-regulated and exhibited 2.19-5.52 fold enhancement in expression.
ERKs, they discovered, phosphorylate the transcription factor Elk1
, which leads to expression of Blimp-1 (Figure 3).
There was also increased expression of phosphorylated MEK1/2 and Elk1
in the transformant cells.