CREB2F, SRF, AKNA, CRTC2, TCF20, and SPDEF transcription factors were observed in prenatal ESTs and also ELF5
, NUPR1, BTAF1, TCF12, TFE3, and TCF20 transcription factors were observed in postnatal ESTs.
In the present work, four hub genes were selected including CXCL3, ELF5, PHLPP2, and TIMP1.
As obviously shown in Figure 7(a), the mRNA expression of CXCL3, ELF5, and TIMP1 significantly increased in CRC tissues compared with matched adjacent normal tissues, whereas PHLPP2 mRNA expression was decreased in CRC tissues; and these results were further confirmed by TCGA database (Figure 7(b)).
Too much of Elf5 or Tfap2c in proportion to Eomes triggered TSCs to differentiate.
These new insights reveal a role for Elf5 as a molecular switch governing the balance between TSC proliferation and differentiation, thereby explaining how the same transcription factors can drive different outcomes for the cell --simply by altering their relative abundance.
Treatment, gene Fold change Dex PRR16 11.71 GMPR 10.39 PNMT 9.46 TDRD9 8.84 PER1 8.60 FRMD4A -9.23 TMEM191B -15.05 NEUROG1 -16.06 ELF5
-19.49 ZNF775 -25.45 Gen CACNA1I 20.67 MSMB 19.54 NPPC 9.39 ALPPL2 9.24 CA12 8.95 FOXB1 -23.44 ATN1 -28.07 SYNPO -35.99 GRIN1 -37.20 ZNF775 -40.56 Dex + Gen MSMB 30.26 MICALCL 16.38 CACNA1I 15.48 CAMP 12.98 DHRS3 11.49 SP5 -17.21 NEUROG1 -17.68 TMEM191B -18.02 ELF5
-39.80 ZNF775 -45.33
Sutherland et al., "Socs2 and Elf5
mediate prolactin-induced mammary gland development," Molecular Endocrinology, vol.
Researchers from the Garvan Institute of Medical Research in Sydney found the molecule, known as ELF5
, which can turn genes on or off.
Andres Blanco et al., "Elf5
inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2," Nature Cell Biology, vol.
Based on gene expression direction of 14 genes, namely CCR2, CXCL6, DACT2, ELF5
, ENAH, ESR1, FLT1, LIN28B, NCAM1, NOX4, SERPINA1, TLE1, TLR7, XRCC5, it can be concluded that Rhodiola may have beneficial effect in cancer, that is in line with growing body of evidence about antitumor activity of Rhodiola and salidroside [Cai et al., 2012; Zhang et al., 2013; Liu et al., 2012; Bocharova et al., 1995; Dement'eva and laremenko, 1987].
In this case, the transcription factor known as 'ELF5
' inhibits sensitivity to oestrogen very early in the life of a breast cancer cell.
The protein, called Elf5
, inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to the research conducted at the University at Buffalo and Princeton University.