ELF1

ELF1

A gene on chromosome 13q13 that encodes an E26 transformation-specific transcription factor, which is primarily expressed in lymphoid cells and, depending on the context, up- or downregulates transcription of various genes. ELF1 activates LYN and BLK promoters, and it may be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. It is also a less preferred gene symbol for what is now designated as EFNA2, see there.
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[DELTA]CT values were obtained by normalization to the mean of three internal reference genes GAPDH, HMBS, and ELF1. Next, AACT values were obtained by normalization to [DELTA]CT values of appropriate control samples.
Cancer related (15 genes--43%) Hoxb13, Hmg20b, Cxcl16, Uimc1, Elf1, Foxp1, Ptgdr, Psmd8, Peg3, Myo15, Lig1, Ptbp2, Kif2c, Grhpr#, Fah# Enzymes (5 genes--14%) Dck, Zdhhc4, Pik3c2g, Grhpr#, Fah# Diverse functions (7 genes--20%) Adipogenesis Aamdc Nuclear Rny1, Polr1d, Nol12, Notch signaling Dtx2 Vascular remodeling Reck/St15 Ig related S72845 Unknown function (10 genes--29%) AK010802, AK007003, AK016406, AK021335, AK015506, AK009275, AK007343, AK006390, AK006570, AK005580 Bolded gene names correspond to genes that fits into two groups (because are cancer related and also enzymes).
Expression of target genes was normalized relative to the expression of elf1 ([DELTA]Ct = Ctvtg gene--Ctefl1).
(The mean difference in blood lead levels within each low, medium, and high contamination category for ELF1 = 0.7, 1.9, 3.2 [micro]g/dL, and for ELF2 = 1.7, 0.8, and 2.9 [micro]g/dL, respectively.) The results for both environmental factors are similar.