EIF1AX

EIF1AX

A gene on chromosome Xp22.12 that encodes an essential translation initiation factor required for binding the 43S complex to the 5’ end of capped RNA. EIF1AX is required for the maximum rate of protein biosynthesis; it enhances ribosome dissociation into subunits and stabilises the binding of the initiator Met-tRNA(I) to 40S ribosomal subunits.
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Esta enfermedad se puede generar por herencia genetica o por radiacion, y se ven afectados genes como: RET, BRAF, RAS, EIF1AX, PPM1D y CHEK2 y translocaciones que afectan PPARg, NTRK1, NTRK3, THADA y FGFR2, ademas de alteraciones moleculares como cadherina epitelial, molecula neural de adhesion celular (N-CAM), p-catenina, p53 y p63 [1,3].
El CPT presenta mutaciones patogenas bien caracterizadas, incluidas mutaciones en BRAF, RAS, EIF1AX, PPM1D y CHEK2 y translocaciones que afectan BRAF, PPARg, NTRK1, NTRK3, THADA y FGFR2 [1].
With progress in understanding the molecular landscape of the tumor and the development of treatments targeting the pathways involving GNAQ/GNA11, BAP1, EIF1AX, SF3B1 mutations and epigenetic mechanisms, in the near future it may be possible to prevent the progression of micrometastases.
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.
151) Various studies, however, are being undertaken and new PTC driver gene mutations such as EIF1AX have been introduced, so that existence of PTC with no oncogenic driver is close to extinction.
We also tested 5 housekeeping genes [LMNB1, lamin B1; EIF1AX, eukaryotic translation initiation factor 1A, X-linked; CASC3 (also known as MLN51), cancer susceptibility candidate 3; PPIA; and PGK1, phosphoglycerate kinase 1] as endogenous controls (data not shown).