EGR2


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EGR2

A gene on chromosome 10q21.1 that encodes a DNA-binding nuclear protein of the EGR family of C2H2-type zinc-finger transcriptional regulators. EGR2 acts as an E3 SUMO-protein ligase, helping SUMO1 conjugation to its co-regulators NAB1 and NAB2; NAB sumoylation downregulates EGR2’s transcriptional activity.
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Transcription Adjusted Motif ID factor p value p value WT1_MOUSE.H11MO.1.A Wt1 8.014E-06 0.004246 EGR2_MOUSE.H11MO.0.A Egr2 5.517E-05 0.02887 ZN281_MOUSE.H11MO.0.A Zn281 5.737E-05 0.03001 ZIC1_MOUSE.H11MO.0.B Zic1 7.868E-05 0.04092 SP5_MOUSE.H11MO.1.C Sp5 9.138E-05 0.04737 Figure 1: Global expression patterns of genes at the nine time points of osteoblast differentiation.
Virtue et al., "The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation," Cell Death and Differentiation, vol.
Johnson, "EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin," Journal of Cellular Biochemistry, vol.
EGR2 is a zinc-finger transcription factor that regulates the expression of myelin proteins.
Endochondral Actin Focal ossification cytoskeleton adhesion VEGFA FGF2 COL11A1 ADAMTS4 FGFR1 COL3A1 PLAT4 TMSB4X COL4A1 COL10A1 GNA13 COL4A2 TGFB2 PDGFA COL4A4 PTHrP FGF1 COL5A1 FGF2 ENAH COL5A2 C4ST1 MSN COL1A1 FGFR1 GSN LAMC2 PDGFRB PDGFRB THBS2 COL1 KRAS CAV2 MRAS ARHGAP5 SOS2 PTEN AKT3 PDGFA PDGFC PGF ITGA2 PDGFRB RAP1B MAPK8 TGF[beta] MAPK signaling signaling Adipogenesis SMURF1 MAPK8 FOXO1A MAPK8 NGFB TRIB3 SKP1 PDGFRB PCK2 NEDD9 RASA2 EGR2 ETS1 SOS2 DDIT3 KLF11 KRAS GADD45A ATF3 MRAS GADD45B FOSB NF1 HIF1A SKIL RAP1B IRS1 SMURF1 DUSP1 MEF2D ZFYVE16 DDIT3 FAS HSPB1 SPOCK IL1A FAS TGFB2 MAP313 ZAK AKT3 MAP3K8 GADD45A Table 2: Genes involved in osteogenesis-related pathways that are downregulated in CYD-treated hMSCs.
Second-generation DNA sequencing technology was applied for gene analysis, and 72 genes (e.g., PMP22 , MPZ , LITAF , and EGR2 ) related to CMT were examined.
As a member of the EGR family, EGR3 maybe a crucial transcriptional factor for T cells, with high similarity with EGR2 [72].
In another recent study, the oncogenic miR-17-92 cluster (which carries six miRNAs: -17, -18a, -19a, -20a, -19b1, and -92a) has been directly associated with the process of monocyte to macrophage differentiation, in which PU.1 and Egr2 are also involved [32].
Svaren, "Direct regulation of myelin protein zero expression by the Egr2 transactivator," Journal of Biological Chemistry, vol.