EGR1


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EGR1

A gene on chromosome 5q31.1 that encodes a DNA-binding nuclear protein of the EGR family of C2H2-type zinc-finger transcriptional regulators. EGR1 activates the transcription of target genes whose products are required for mitogenesis and differentiation.
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Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus.
5] Human genes: F3, coagulation factor III (thromboplastin, tissue factor); KRAS, v-KI-ras 2 Kirsten rat sarcoma viral oncogene homolog; TP53, tumor protein p53; PTEN, phosphatase and tensin homolog; STK11, serine/threonine kinase 11; HPSE, heparanase; EGR1, early growth response 1; EGFR, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian).
Then, we sought to determine whether the failure of expression of essential IEGs, such as Arc , c-fos , and Egr1 , was involved in memory deficits.
For example, intrahippocampal administration of antisense IEG oligonucleotides ( Arc and c-fos ) or germline disruption of the IEGs c-fos , tissue plasminogen activator, or Egr1 impairs the consolidation of long-term memory formation but does not affect learning or short-term memory.
Abbott said that its Vysis EGR1 FISH Probe Kit can identify which AML patients have the chromosomal abnormality upon diagnosis and provides physicians with another clinically validated tool to assess a patient's overall prognosis.
The Vysis EGR1 FISH Probe Kit is intended to detect deletion of LSI EGR1 probe target on chromosome 5q in bone marrow specimens and may be used, in addition to cytogenetics, other biomarkers, morphology and other clinical information, at the time of acute myeloid leukaemia (AML) diagnosis as an aid in determining prognosis.
This conclusion is supported by the fact that although Pdx1, Egr1, Chgb, Pax4, and Actb genes are expressed by MIN6 131 cells and Pdx1, Egr1, Chgb, and Actb transcripts are detectable in the corresponding CM samples, Pax4 is not.
Our results for a number of beta cell gene transcripts (including those for Pdx1, Egr1, and Chgb) indicated that the degrees of gene expression reflect the numbers of MIN6 131 cells conditioning the medium.
Repression of MYC and the early growth-response gene EGR1 in this group may further negatively regulate E2F1 and its target gene expression.
EGR1 Target genes in prostate carcinoma cells identified by microarray analysis.