The relative gene expression of growth factors Egr1
(a), Fgf2 (b), and Fgf7 (c) shows significant upregulation in inflamed colons as compared to both control and uninflamed colons of colitis-induced animals.
We found a downregulation of the Egr1
gene in the PTSD-vehicle group compared to the PTSD-midazolam group.
Virtue et al., "The transcription factors Egr1
and Egr2 have opposing influences on adipocyte differentiation," Cell Death and Differentiation, vol.
In contrast, genes involved in stem cell maintenance, such as cell adhesion molecules, WNT, and Notch-signaling pathway components, CDH1, SERPINF1, LEF1, FRZB1, KRT19, SOD2, and EGR1
, were overexpressed in the limbal crypt .
NGFI-A (also known as Egr1
, krox24, zif/268, and TIS8), a transcription factor belonging to the early growth response family , is associated with stabilisation of LTP and learning [151, 152].
"Finally we have been able to assemble the regulatory regions of genes, such as FoxP2 and egr1
, that are of interest to us and others in vocal learning behaviour," Jarvis said.
The transcription factor EGR1
regulates metastatic potential of v-src transformed sarcoma cells.
Among these genes, several miRNAs targeted CD28 (hsa-miR-143-3p, -27b-3p, -15b-5p, and -195-5p), CD4 (hsa-miR-181a-5p), ICOS (hsa-miR 27b-3p and -let-7f-5p, -7e-5p, and -7d-5p), CTLA4 (hsa-miR-143-3p), EGR1
(hsa-miR-143-3p, -146a-5p, -181a5p, -199b-3p, and -199a-3p), and AKIRIN2 (hsa-miR-1395p, -27b-3p, and -181a-5p).
Early growth response factor 1 (Egr1
), a member of the immediate early response family, is highly expressed in a variety of kidney cells, including kidney proximal tubular epithelial cells .
In support of this view, the present RNA-Seq data indicated that EGR1
(GeneID 1958), EGR2 (GeneID 1959), PDGFC (GeneID 56034), and PDGFD (GeneID 80310) were all downregulated by E2.
Brivoligide inhibits the activity of EGR1
, a transcription factor that plays a critical role in establishing and maintaining pain following injury or trauma.