EGFR


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EGFR

Farlex Partner Medical Dictionary © Farlex 2012

EGFR

A gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.

Molecular pathology
EGFR mutations are associated with lung cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

EGFR

Abbreviation for epidermal growth factor receptor.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

eGFR

estimated glomerular filtration rate.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
There are significant differences in the prevalence of EGFR gene mutations in patients with lung cancer from different ethnic groups.
The NGS results from 1208 lung cancer specimens submitted between April 2013 and December 2016 were analyzed for coexisting mutations within EGFR, MAPK, and mTOR pathways.
The baseline eGFR was calculated from baseline SCr using the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation:[17],[18] eGFR (ml*min −1*1.73 m −2) = 141 x min (SCr/k, 1)a x max (SCr/k, 1)−1.209 x 0.993age x 1.018 (if female) x 1.159 (if black) where SCr is serum creatinine (mg/dl), k is 0.7 for females and 0.9 for males, a is −0.329 for females and −0.411 for males, min indicates the minimum of SCr/k or 1, and max indicates the maximum of SCr/k or 1, which was performed by the CKD-EPI calculator on the website (http://www.qxmd.com/calculate-online/nephrology/ckd-epi-egfr).
The company said the cobas EGFR Mutation Test v2 companion diagnostic test (CDx) test is performed on the cobas 4800 System, which offers high-performance PCR amplification and detection coupled with software that automates result interpretation and reporting.
"If anything, there was more effect in the low eGFR group than in the high eGFR group [HRs, 0.92 and 0.70, respectively; 0.65, 0.71, 0.95, and 0.84 for the four eGFR groups, respectively]," he added, noting that the same was true for the cardiovascular death and MI components of the primary endpoint.
EGFR gene expression level in normal blastocysts and 2-cell embryos of the vitrified-warmed group and control groups was tested for statistical significance using the Chi-square ([chi square]) test by SPSS program (SPSS 11.5; Chicago, IL, USA).
The MDRD equation provides an eGFR based on serum creatinine concentration, age, sex and is normalised adult body size of 1.73[m.sup.2] (3).
Despite this, significant resourcing is directed into eGFR screening for outpatients by our centre.
Genomic DNA was extracted, and PCR amplified the EGFR gene region using the exon 3 or exon 9 DNA primers which are listed in the Supplementary Table.
Objectives: First objective was to compare eGFR by Updated Schwartz (US) and Simple Height Independent (SHID) formula with Original Schwartz (OS) in children with Severe Acute Malnutrition (SAM).
Tagrisso is a third-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with clinical activity against central nervous system (CNS) metastases, for the 1st-line treatment of adult patients with locally-advanced or metastatic non-small cell lung cancer (NSCLC) whose tumours have EGFR mutations (exon 19 deletions or exon 21 (L858R) substitution mutations).