EFNB2

EFNB2

A gene on chromosome 13q33 that encodes ephrin-B2, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNB2 binds to EPHA3, EPHA4, and EPHB4 receptors; with EPHB4 it plays a central role in heart morphogenesis and angiogenesis by regulating cell adhesion and migration. EPHB4-mediated forward signalling controls cellular repulsion and segregation from EFNB2-expressing cells. It may play a role in constraining the orientation of longitudinally projecting axons.
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Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.
Il10 and Efnb2 genes were also shown to be regulated by miR-27b-3p.
Genes AIRmax pristane FDR AIRmax pristane FDR 120 days/control 170 days/control (FC) (FC) MMP13 10.4 0.001 10.32 0.000587 C5AR1 3.36 0.002 -- -- P2RX7 3.25 0.009 -- -- GPSM3 3.2 0.0003 -- -- C5AR2 3.19 0.004 3.41 0.015568 S1PR1 -3.42 0.000778 -3.63 0.036394 IL-10 -3.93 0.002 -- -- BMP2 -4.31 0.001 -5.11 0.000521 CD69 -6.04 0.002 -- -- EFNB2 -10.24 0.000114 -13.98 0.000003 IL-6 -24.6 0.0002 -15.45 0.003381 TGFB2 -40.36 2.05E--07 -44.4 7.58E--07
Arteries and arterioles express ephrin B2 (Efnb2) and are negative for Emcn expression.
The EFNB2 gene was observed at the upstream region and SLC10A2 gene was observed on the downstream region.
According to the published mRNA sequences, mouse Efnb2 (gene access number: NM_010111.5) and Ephb4 (gene access number: NM_001159571.1) genes were synthesized using DNA synthesis technology and overlapping PCR by ThermoFisher Scientific, Inc.
Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.
High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas.
For example, they interact with melanocytes, outer root sheath cells, and DP cells via the KIT, EFNB2, and SHH signaling pathways, respectively [31].
The DEGs positively regulated by DE-lncRNAs (e.g., Efna1 and Efnb2) were mainly enriched in a set of biology processes about the development of blood vessel, such as vasculature development and blood vessel morphogenesis (Table 2).
The DEGs positively regulated by DE-lncRNAs were mainly enriched in the functions about the development of blood vessel (e.g., Efna1 and Efnb2), as well as the pathways of cholesterol biosynthesis (e.g., Cyp51 and Fdps) and elastic fibre formation (e.g., Fbln1, Fbln2, and Fbln5).
The function of blood vessel development was significantly enriched by a set of DE-lncRNA genes, such as Efna1 and Efnb2. During aging, angiogenesis is delayed, and capillary density as well as newly deposited collagen is decreased [36].