EFNA1

EFNA1

A gene on chromosome 1q21-q22 that encodes ephrin-A1, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA1 plays an important role in angiogenesis (by RAC1 GTPase activation and vascular endothelial cell migration and assembly) and tumour neovascularisation (by activating EPHA2 and downregulating it). It induces tyrosine phosphorylation, leading to its internalisation and degradation, is induced by TNF and IL1B/interleukin-1 beta, and binds to EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7 receptors.
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The remaining CpGs of the top 10 CpGs annotated to the upstream region of SEMA4G (cg05962511), C19orf66 promoter (cg13480898), EFNA1 (ephrin A1) gene body (cg07207669), SQSTM1 (sequestosome 1) 5'UTR (cg01225779), EML2 (echinoderm 486 microtubule associated protein like 2) gene body (cg06381803), UNKL (unk like zinc finger) TSS200 (cg09183146), MYEOV (myeloma overexpressed) promoter (cg08759026), and SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) 5'UTR (cg17489312).
ENSMUSG00000086859 targeted genes like Efna1, Fbln1, and Fbln2.
The DEGs positively regulated by DE-lncRNAs (e.g., Efna1 and Efnb2) were mainly enriched in a set of biology processes about the development of blood vessel, such as vasculature development and blood vessel morphogenesis (Table 2).
The DEGs positively regulated by DE-lncRNAs were mainly enriched in the functions about the development of blood vessel (e.g., Efna1 and Efnb2), as well as the pathways of cholesterol biosynthesis (e.g., Cyp51 and Fdps) and elastic fibre formation (e.g., Fbln1, Fbln2, and Fbln5).
The function of blood vessel development was significantly enriched by a set of DE-lncRNA genes, such as Efna1 and Efnb2.
I consider change in either overall freedom or change in one of three underlying component scores EFNA1. EFNA2.
TABLE 1 Components of the Economic Freedom of North America Index Area 1 (EFNA1).
The genes containing very highly selective SNPs with p-value <0.01 (nearly top 1% SNPs) in all traits and p-value <0.001 (nearly top 0.1%) in any traits were phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2), and ADAM metallopeptidase domain 12 (ADAM12).
The EFNA composite index is comprised of three area indices: size of government (EFNA1); distortionary taxation and takings (EFNA2); and labor market freedom (EFNA3).
Columns 2, 3, and 4 report results using each of the three economic freedom areas: size of government (EFNA1), distortionary taxation (EFNA2), and market freedom (EFNA3).
(8) Meanwhile, standard deviation increases in EFNA1 and EFNA2 are associated with an approximately half and third standard deviation increase in income per capita, respectively.
Meanwhile, standard deviation increases in EFNA1 and EFNA2 are associated with approximately half a standard deviation drop in the unemployment rate.