The vasodilator effects of daidzein and daidzin were also shown to be independent of EDRF
, GC/cGMP, AC/cAMP, [BK.sub.Ca], [K.sub.V], and [K.sub.IR] channels (Deng et al.
 and Martin et al. demonstrated that suppression of constrictor responses to several agonists such as PE in the intact vascular endothelium may be due continuously basal release of endothelium-derived relaxing factor (EDRF
) from endothelial cells.
The region saw pounds 929m invested in 1,802 projects under Objective 1, and has benefited hugely from the European Social Fund (ESF) and European Regional Development Fund (EDRF
Ambit boss Neil Armstrong said: "Toffee Factory is completely in line with my business as it provides the ideal workspace for us primarily due to the community that I will be around within the building as well as the facilities that will be provided - it is definitely going to have a buzz!" The site is being developed by 1NG on behalf of Newcastle City Council and One North East with funding from the European Union's EDRF
Competitiveness Programme, One North East and Newcastle City Council.
L-NAME, an inhibitor of EDRF
synthesis did not affect the relaxation by testosterone.
The effect of methylmetcury (CH3HgCl) on the production of endotheliumderived relaxing factor (EDRF
) by cultured human umbilical vascular endothelial cells based on its anti-aggregatory effect on human platelets.
The essential role of NO, as the elusive endothelium-derived relaxing factor (EDRF
), was the topic of research that won the 1998 Nobel Prize in Physiology or Medicine (15-17).
It is known that nitric oxide (the endothelium derived relaxing factor, EDRF
) (20) activates soluble guanylyl cyclase, causing the formation of cyclic GMP and subsequently vascular relaxation (21).