EDNRA


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EDNRA

A gene on chromosome 4q31.22 that encodes endothelin-A receptor, a member of the endothelin receptor group of G-protein-coupled receptors, located primarily in the vascular endothelial cells where they play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation.

Molecular pathology
EDNRA polymorphisms have been linked to migraine headache resistance.
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Logistic regression analysis for EDNRA rs5335 did not show any significant link with LAS development neither before nor after adjustment for atherosclerosis risk factors (P > 0.05).
EDNRA rs5335 SNP was not associated with stroke development in the female subgroup (P > 0.05).
Due to influential role of the endothelin pathway in hypertension development, we also investigated the association between EDN1 and EDNRA gene polymorphisms and ischemic stroke development in patients with and without AH (Table 6).
No link between EDNRA rs5335 genotypes and BMI, BP indices, coagulogram parameters, fasting glucose, and blood plasma lipid profile in stroke patients was found (Table 8).
Prediction analysis of EDNRA rs5335 by the SNPinfo tool demonstrated that this SNP is possibly located in hsa-miR-27a-3p and hsa-miR-27b-3p binding sites (score--153.0).
The polymorphic site rs5335 is located within the 3'-UTR of the EDNRA gene and leads to cytosine/guanine conversion at position 61,772.