EDN1

EDN1

A gene on chromosome 6p24.1 that encodes endothelin 1, a potent vasoconstrictor of the endothelin family, which is produced by vascular endothelial cells.
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We measured blood levels of 10 cytokines including 6 pro-inflammatory cytokines [interleukin-1 (IL-1; gene name: IL1), interleukin-6 (IL-6; gene name: IL6), tumor necrosis factor-[alpha] (TNF-[alpha]; gene name: TNF), toll-like receptor-2 (TLR-2; gene name: TLR2), CD40 ligand (CD40L; gene name: CD40LG), and intercellular adhesion molecule-1 (ICAM-1; gene name: ICAM1)], two procoagulant cytokines [tissue factor (F3; gene name: F3) and plasminogen activator inhibitor-1 (PAI-1; gene name: SERPINE1)], and two vasoconstrictors [endothelin-1 (ET-1; gene name: EDN1) and angiotensin converting enzyme-1 (ACE-1; gene name: ACE)].
[73] proved that the miR-130/301/PPAR[gamma] axis in PAECs regulated various vasoactive factors, most significantly endothelin-1(EDN1), which serves as a vital regulator of vascular communication between PAECs and PASMCs, vasomotor tone, and PH manifestation in vivo.
In recent years, a wide range of case-control studies to test the association between various single nucleotide polymorphisms (SNPs) of the ET-1 (EDN1) and its receptor (EDNRA and EDNRB) genes and development of arterial hypertension (AH) [5, 6], pulmonary hypertension [7], myocardial infarction [8], diabetic retinopathy [9] and nephropathy [10], metabolic syndrome [11], and hemorrhagic stroke [12] have been carried out.
Genes expressed more highly in OECs were Jagged 1 (JAG1), JAG2, placental growth factor (PGF), endothelial cell-specific molecule 1 (ESM1), neurite growth-promoting factor 2 (MDK), inhibin beta A (INHBA), growth differentiation factor-3 (GDF3), pre-B-cell colony-enhancing factor 1 (PBEF1), endothelin 1 (EDN1), interleukin 32 (IL32), heparin-binding EGF-like growth factor (HBEGF), chemokine (C-X-C motif) ligand 1 (CXCL1), chemokine (C-C motif) ligand 2 (CCL2), CCL14, CCL15, bone morphogenetic protein 2 (BMP2), BMP4, and BMP6, whereas genes expressed more highly in MSCs were wingless-type MMTV integration site family, member 5A (WNT5A), CXCL5, vascular endothelial growth factor (VEGF), CCL20, angiopoietin 1 (ANGPT1), growth differentiation factor 5 (GDF5), and WNT5B (Figure 7).
miR-567 SPTBN1; DUSP1; BCHE; LPHN2 miR-141-3p H3F3B; TCEAL2; MYH10; LHFP; LPHN2; CCL2; KLF9 miR-454-3p DPYSL2; HOXA5; FKBP11; SRPX; EDN1; LDLR; CAV2; BMPR2; SLC2A1 SERPINE2; PLEKHC1; SPTBN1; H3F3B; miR-590-3p TMEM47; TIMP3; COL3A1; CXCL13; ETS2; CELSR3; LPL; SMAD6; BMPR2; LPHN2; SASH1.
Previous work demonstrated that two types of molecular signals, called Jagged-Notch and Endothelin1 (Edn1), are critical for shaping the face.
Previous work from the Crump and other labs demonstrated that two types of molecular signals, called Jagged-Notch and Endothelin1 (Edn1), are critical for shaping the face.
No evidence of an association between two genes, EDN1 and ACE, and childhood-onset mood disorders.
"Prosthesis in hernia surgery" In abdominal wall hernias.Principles & management" Chapter-3 edn1. Edt, Bendavid R, Abrahamson J, Phillip EH.
EDN1 Lys198 ASN is associated with diabetic retinopathy in type 2 diabetes.
Of the three endothelin peptides, endothelin-1, -2, and -3, endothelin-1 (EDN1) is the predominant isoform in the vascular system.