S1PR4

(redirected from EDG6)

S1PR4

A gene on chromosome 19p13.3 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor for sphingosine 1-phosphate, a bioactive lysophospholipid that regulates cell proliferation, apoptosis, motility and neurite retraction. It acts intracellularly as a second messenger and extracellularly as a receptor ligand, and it elicits diverse physiologic effects on most types of cells and tissues.
References in periodicals archive ?
Lipp, "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue," Genomics, vol.
Lipp, "A lymphoid tissue-specific receptor, EDG6, with potential immune modulatory functions mediated by extracellular lysophospholipids," Current Topics in Microbiology and Immunology, vol.