LPAR2

(redirected from EDG4)

LPAR2

A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid (LPA), a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion. LPAR2 contributes to Ca2+ mobilisation, a critical cellular response to LPA in cells, by association with Gi and Gq proteins.
References in periodicals archive ?
Fukushima et al., "Characterization of [lpa.sub.2] (Edg4) and [lpa.sub.1]/[lpa.sub.2] (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to [lpa.sub.2]," Molecular and Cellular Biology, vol.
Zhang, "Expression and significance of Edg4 and Edg7 in the placentas of patients with hypertensive disorder complicating pregnancy, " Zhonghua Fu Chan Ke Za Zhi, vol.
O'Connor, "[LPA.sub.2] (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than [LPA.sub.1] (EDG2) in breast carcinoma cells," American Journal of Physiology--Cell Physiology, vol.