S1PR1

(redirected from EDG1)

S1PR1

A gene on chromosome 1p21 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which is highly expressed in endothelial cells. It binds the sphingosine-1-phosphate with high affinity and high specificity, and may be involved in regulating endothelial cell differentiation. Receptor activation induces cell–cell adhesion.
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Expression differences in EDG1 have been previously reported between a high-marbled steer group and a low-marbled steer group in musculus longissimus muscle across all ages (Sasaki et al.
Novel SNP in 5' flanking region of EDG1 associated with marbling in Japanese Black beef cattle.
These experiments confirmed that the genes EDG1, PAK2, and the previously unidentified TRAC-1 were normally expressed in the lymphoid system and that truncated versions of their proteins could repress T-cell receptor signaling in T-cells.