S1PR1

(redirected from EDG1)

S1PR1

A gene on chromosome 1p21 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which is highly expressed in endothelial cells. It binds the sphingosine-1-phosphate with high affinity and high specificity, and may be involved in regulating endothelial cell differentiation. Receptor activation induces cell–cell adhesion.
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In particular, one SNP, Hapmap39048-BTA-99764 was located within EDG1 gene on BTA3, which was reported to be a positional function candidate gene responsible for marbling [20].
EDG1 is a functional sphingosine-1-Phosphate receptor that is linked via G(i/o) to multiple signalling pathways, including phospholipase C activation, [Ca.
3 606167 No definido accumulation protein) EDG1 S1P1 (S1P 1p21 601974 No definido {Endothelial receptor 1) differentiation gene 1) EDG2 VZG1(ventricular 9q 602282 No definido zone gene 1), LPA1 EDG3 S1P3 9q22.
Novel SNP in 5' flanking region of EDG1 associated with marbling in japanese Black beef cattle.