EDEM3

A gene on chromosome 1q25 that encodes an enzyme which accelerates endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation by proteasomes. It is thought to have mannosidase activity.

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When trimming of an outermost Man residue occurs on the C-arm of high mannose-type glycans by EDEM1 or EDEM3, it binds OS-9 and XTP3-B.

Intracellular lectins are involved in quality control of glycoproteins

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Edelman, Gerald M.
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